Anti-GABRD antibody [N151/3] (ab93619) | Abcam (2024)

Overview

• Product name

  Anti-GABRD antibody [N151/3]
  See all GABRD primary antibodies

• Description

  Mouse monoclonal [N151/3] to GABRD

• Host species

  Mouse

• Tested applications

  Suitable for: WB, ICC/IFmore details

• Species reactivity

  Reacts with: Rat, Human
  Predicted to work with: Cow

• Immunogen

  Synthetic peptide corresponding to Rat GABRD aa 15-34.
  Sequence:

  CTQPHHGARAMNDIGDYVGSN

  Run BLAST with Run BLAST with

• Positive control

  • Rat brain lysate

• General notes

  The clone number has been updated from S151-3 to N151/3, both clone numbers name the same antibody clone.

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Properties

• Form

  Liquid

• Storage instructions

  Shipped at 4°C. Store at -20ºC.

• Storage buffer

  Preservative: 0.09% Sodium azide
  Constituents: 50% Glycerol (glycerin, glycerine), PBS

• Concentration information loading...

• Purity

  Protein G purified

• Clonality

  Monoclonal

• Clone number

  N151/3

• Isotype

  IgG2a

• Research areas

  • Neuroscience
  • Neurotransmitter
  • Amino Acids
  • GABA

  • Neuroscience
  • Neurotransmission
  • Receptors / Channels
  • Ligand-Gated Ion Channels
  • GABA Receptors

  • Neuroscience
  • Processes

Associated products

• Compatible Secondaries

• Isotype control

  • Mouse IgG2a, kappa monoclonal [MG2a-53] - Isotype control (ab18415)

• Positive Controls

  • Rat brain normal tissue lysate - membrane extract (ab29473)

Applications

Target

• Function

  GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

• Involvement in disease

  Defects in GABRD are the cause of susceptibility to generalized epilepsy with febrile seizures plus type 5 (GEFS+5) [MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.
  Defects in GABRD are the cause of susceptibility to idiopathic generalized epilepsy type 10 (IGE10) [MIM:613060]. A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain.
  Defects in GABRD are the cause of susceptibility to juvenile myoclonic epilepsy type 7 (EJM7) [MIM:613060]. A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.

• Sequence similarities

  Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRD sub-subfamily.

• Cellular localization

  Cell junction > synapse > postsynaptic cell membrane. Cell membrane.

• Information by UniProt

• Database links

  • Entrez Gene: 2563 Human
  • Entrez Gene: 29689 Rat
  • Omim: 137163 Human
  • SwissProt: O14764 Human
  • SwissProt: P18506 Rat
  • Unigene: 113882 Human
  • Unigene: 10927 Rat

• Alternative names

  • GABA(A) receptor subunit delta antibody
  • Gabrd antibody
  • Gamma aminobutyric acid GABA A receptor delta antibody

  see all

Images

Protocols

Datasheets and documents

References (1)